A comparative mapping of enzymes involved in hexosemonophosphate shunt and citric acid cycle in the brain.

REPORTS of preceding investigations (FRIEDE, 1959~2, 1961 c; FRIEDE and FLEMING, 1962) have contained detailed charts of the distribution of several enzymes in the brain. The purpose of this paper is to compare enzyme patterns with each other and to describe similarities and, particularly, differences of the patterns that were observed. The regional patterns in the brain of seven enzymes which are concerned with glucose metabolism were studied and compared. Most of the data were obtained from histochemical series from rhesus monkey and human brains. These were compared with tissue homogenate assays. The enzymes studied were cytochrome oxidasef succinic dehydrogenase, DPN-diaphorase, TPN-diaphorase, malic dehydrogenase glucose-6-phosphate dehydrogenase, 6-phosphogluconic dehydrogenase and lactic dehydrogenase. In order to render this article more complete, some previously published data have been included.